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Featured Cases: Multidrug-Resistant (MDR) Gram-Negative Pathogens
Our Guest Author is Lisa L. Maragakis, MD, MPH, Assistant Professor of Medicine Division of Infectious Disease at the Johns Hopkins University School of Medicine.

At the conclusion of this audio activity, participants should
be able to:

Describe the risk factors and outcomes associated with multiple drug-resistant (MDR) Acinetobacter baumannii infections
Explain the importance of controlling the source of completed infections, in conjunction with antibiotic selection, to prevent clinical failures and the emergence of antimicrobial resistant
Discuss the clinical rationale for considering the use of extended infusion of beta-lactam antibiotics when treating MDR gram-negative infections

This discussion, offered as a downloadable audio file and companion transcript, covers the important issues related to MDR Gram-Negative Pathogens in the format of case-study scenarios for the clinical practice. This program is a follow up to the May 2010 eInfections Review newsletter—Multidrug-Resistant (MDR) Gram-Negative Pathogens.

Unlabeled/Unapproved Uses

The author has indicated that this presentation will include off-label discussion meropenem infusion and dosing.
Lisa L. Maragakis, MD, MPH
Associate Professor of Medicine
Division of Infectious Diseases
Director, Antibiotic Management Program
Associate Hospital Epidemiologist
The Johns Hopkins University
School of Medicine
Baltimore, MD
     

Guest Faculty Disclosures

Lisa L. Maragakis, MD, MPH, has disclosed no relevant financial relationships to disclose.
Release Date
June 2, 2010

Expiration Date
June 1, 2012

Next Issue
July 6, 2010
Paul G. Auwaerter, MD
Associate Professor of Medicine
Clinical Director,
Division of Infectious Diseases and General Internal Medicine
The Johns Hopkins University
School of Medicine
Baltimore, MD
John G. Bartlett, MD
Professor of Medicine
Department of Medicine
The Johns Hopkins University
School of Medicine
Baltimore, MD
Sara E. Cosgrove, MD, MS
Associate Professor of Medicine
Division of Infectious Diseases
Director, Antibiotic Management Program
Associate Hospital Epidemiologist
The Johns Hopkins University
School of Medicine
Baltimore, MD
 accreditation statement
The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

credit designation
Physicians
eNewsletter: The Johns Hopkins University School of Medicine designates this educational activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Podcast: The Johns Hopkins University School of Medicine designates this educational activity for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

disclaimer statement
The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. Use of the Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

SUCCESSFUL COMPLETION
To successfully complete this activity, participants must read the content, then link to the Johns Hopkins University School of Medicine’s CME website to complete the post-test, and evaluation.  Once you receive a passing grade, you can access and print your certificate of credit.  NOTE: If you have already registered for the Hopkins CME programs at the CME Website simply enter the requested information when prompted.

statement of responsibility
The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

intended audience
This activity has been developed for the Primary Care Physician, Internist, and Infectious Disease Specialist.

There are no prerequisites.


internet cme policy
The Office of Continuing Medical Education (CME) at the Johns Hopkins University School of Medicine is committed to protect the privacy of its members and customers. The Johns Hopkins University SOM CME maintains its Internet site as an information resource and service for physicians, other health professionals and the public.

Continuing Medical Education at the Johns Hopkins University School of Medicine will keep your personal and credit information confidential when you participate in a CME Internet based program. Your information will never be given to anyone outside of the Johns Hopkins University School of Medicine’s CME program. CME collects only the information necessary to provide you with the services that you request.

faculty disclosure
As a provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of Johns Hopkins University School of Medicine to require the disclosure of the existence of any relevant financial interest or any other relationship a faculty member or a provider has with the manufacturer(s) of any commercial product(s) discussed in an educational presentation. The Course Director and planning committee have reported the following:

Paul G. Auwaerter, MD – has disclosed that he has served as a consultant Adamas Pharmaceuticals, LifeCell, Schering-Plough, and Wyeth. He has disclosed that he is a stock shareholder of Johnson & Johnson, Merck and Pfizer.
John G. Bartlett, MD – has disclosed that he has served as a consultant for Salient.
Sara E. Cosgrove, MD, MS – has disclosed that she has received grants or research support from Cubist, AdvanDX, and Astellas, and served as a consultant for Theravance/Astellas, Merck, and Forest.
Guest Author's Disclosures

hardware & software requirements
Pentium 800 processor or greater, Windows 98/NT/2000/XP or Mac OS 9/X, Microsoft Internet Explorer 5.5 or later, 56K Modem or better, Windows Media Player 9.0 or later, 128 MB of RAM, monitor settings: high color at 800 x 600 pixels, sound card and speakers, Adobe Acrobat Reader.
If you want to now listen to the eInfections Review podcast, just click on the button above. This will open your Internet browser to play the podcast by streaming the media via the web.

Please note: This podcast file is large so please be patient while the content downloads.
Save the podcast to your computer. Once saved you can manage and play the file like any song or music using your music software (iTunes, Windows Media, Real Player, etc.). You can also transfer the podcast file to your iPod, MP3 player and listen while on-the-go.
Like any RSS subscription,
when you subscribe to
eInfections Review you will automatically receive each new edition, downloaded to your hard drive as soon as it becomes available. You may manage and play the downloaded podcast file like any song or audio file by using your music software (iTunes, Windows Media, Real Player, etc.). You can also transfer the podcast file to your iPod, MP3 player to listen while on-the-go.
Release Date
June 2, 2010

Expiration Date
June 2, 2012

Next Issue
July 6, 2010


COMPLETE THE
POST-TEST


Click on link to download instructions for the posttest and evaluation
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